Kenji Sunagawa Selected Research

Type 1 Angiotensin Receptor

4/2015	Blockade of brain angiotensin II type 1 receptor inhibits the development of atrial fibrillation in hypertensive rats.
11/2014	Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with myocardial infarction-induced heart failure.
2/2014	Telmisartan reduces mortality and left ventricular hypertrophy with sympathoinhibition in rats with hypertension and heart failure.
1/2013	Partially silencing brain toll-like receptor 4 prevents in part left ventricular remodeling with sympathoinhibition in rats with myocardial infarction-induced heart failure.
11/2011	Brain AT1 receptor activates the sympathetic nervous system through toll-like receptor 4 in mice with heart failure.
2/2010	Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats.
12/2009	Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method.
6/2008	Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Sp1.
4/2008	Effects of valsartan or amlodipine on endothelial function and oxidative stress after one year follow-up in patients with essential hypertension.
10/2006	Angiotensin II type 1 receptor blockade attenuates in-stent restenosis by inhibiting inflammation and progenitor cells.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Kenji Sunagawa Research Topics

Disease

52	Heart Failure 01/2022 - 09/2003
35	Hypertension (High Blood Pressure) 01/2022 - 07/2003
30	Myocardial Infarction 01/2019 - 11/2004
26	Inflammation (Inflammations) 01/2019 - 11/2004
21	Stroke (Strokes) 11/2018 - 01/2006
14	Myocardial Ischemia (Ischemic Heart Diseases) 11/2016 - 05/2002
12	Ischemia 01/2019 - 05/2004
12	Hypoxia (Hypoxemia) 01/2019 - 12/2009
12	Infarction (Infarctions) 01/2018 - 08/2003
11	Cardiovascular Diseases (Cardiovascular Disease) 11/2017 - 04/2003
11	Atherosclerosis 05/2014 - 11/2004
10	Hypertrophy 10/2015 - 09/2005
10	Neointima 09/2011 - 09/2005
9	Fibrosis (Cirrhosis) 01/2019 - 04/2006
8	Left Ventricular Dysfunction 01/2016 - 11/2004
7	Obesity 10/2021 - 01/2011
6	AIDS-Related Complex (ARC) 01/2019 - 04/2003
6	Atherosclerotic Plaque (Atheroma) 03/2016 - 10/2007
5	Pulmonary Arterial Hypertension 01/2019 - 05/2009
5	Vascular Remodeling 10/2018 - 01/2006
5	Ventricular Remodeling 11/2016 - 09/2006
5	Rupture 03/2016 - 09/2006
5	Body Weight (Weight, Body) 04/2015 - 06/2002
4	Reperfusion Injury 11/2016 - 10/2007
4	Cardiac Arrhythmias (Arrythmia) 05/2016 - 01/2005
4	Abdominal Aortic Aneurysm 01/2016 - 11/2004
3	Coronary Artery Disease (Coronary Atherosclerosis) 01/2017 - 02/2006
3	Cardiomyopathies (Cardiomyopathy) 01/2016 - 06/2005
3	Cognitive Dysfunction 01/2015 - 01/2012
3	Aneurysm (Aneurysms) 05/2014 - 11/2004
3	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 02/2014 - 10/2002
3	Insulin Resistance 05/2013 - 10/2007
3	Pathologic Constriction (Stenosis) 01/2013 - 12/2007
3	Heart Diseases (Heart Disease) 01/2013 - 07/2004
3	Diabetes Mellitus 07/2009 - 05/2007
3	Vascular Diseases (Vascular Disease) 01/2008 - 09/2006
3	Coronary Occlusion 10/2007 - 05/2002
3	Cardiomegaly (Heart Hypertrophy) 04/2006 - 07/2003
3	Long QT Syndrome 01/2005 - 02/2003

Drug/Important Bio-Agent (IBA)

18	Angiotensin IIIBA 01/2017 - 04/2003
10	SaltsIBA 01/2016 - 01/2005
10	Type 1 Angiotensin ReceptorIBA 04/2015 - 10/2006
10	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2015 - 07/2007
8	Oxygen (Dioxygen)IBA 01/2019 - 09/2003
8	Apolipoproteins E (ApoE)IBA 03/2016 - 11/2004
8	AntioxidantsIBA 01/2015 - 04/2006
8	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 02/2014 - 11/2004
7	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2019 - 01/2003
7	CytokinesIBA 01/2017 - 11/2004
7	Matrix Metalloproteinases (MMPs)IBA 03/2016 - 04/2006
7	Hydralazine (Apresoline)FDA LinkGeneric 04/2015 - 01/2007
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2012 - 06/2005
7	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2012 - 11/2005
6	Transcription Factors (Transcription Factor)IBA 01/2019 - 01/2006
6	Therapeutic UsesIBA 10/2018 - 01/2012
6	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2017 - 06/2009
6	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 07/2014 - 12/2009
6	LipidsIBA 05/2014 - 12/2004
6	Proteins (Proteins, Gene)FDA Link 05/2013 - 10/2007
6	Amlodipine (Norvasc)FDA LinkGeneric 01/2012 - 01/2006
5	salicylhydroxamic acid (SHAM)IBA 01/2018 - 10/2002
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2016 - 12/2004
5	Mitochondrial DNA (mtDNA)IBA 01/2016 - 08/2005
5	Acetylcholine (Acetylcholine Chloride)FDA Link 06/2015 - 11/2005
5	pitavastatin (itavastatin)FDA Link 01/2015 - 08/2010
5	Telmisartan (Micardis)FDA Link 02/2014 - 05/2009
5	CholesterolIBA 07/2013 - 10/2007
5	Atorvastatin (Lipitor)FDA Link 01/2012 - 01/2008
5	azelnidipineIBA 01/2012 - 09/2006
4	Indicators and Reagents (Reagents)IBA 01/2022 - 07/2006
4	MonocrotalineIBA 01/2019 - 05/2009
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2017 - 11/2005
4	Insulin (Novolin)FDA Link 01/2015 - 10/2007
4	olmesartanIBA 01/2012 - 09/2006
4	NF-kappa B (NF-kB)IBA 05/2009 - 06/2005
4	rho-Associated KinasesIBA 11/2008 - 05/2005
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 03/2016 - 10/2012
3	Pioglitazone (Actos)FDA Link 03/2016 - 10/2012
3	Phosphotransferases (Kinase)IBA 01/2015 - 01/2011
3	Blood Glucose (Blood Sugar)IBA 01/2015 - 09/2006
3	AdiponectinIBA 01/2015 - 10/2012
3	Glucose (Dextrose)FDA LinkGeneric 07/2014 - 06/2012
3	ApolipoproteinsIBA 05/2014 - 11/2010
3	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 03/2013 - 07/2010
3	Sirolimus (Rapamycin)FDA Link 01/2013 - 01/2009
3	Pharmaceutical PreparationsIBA 10/2012 - 01/2005
3	Superoxide DismutaseIBA 01/2012 - 12/2008
3	ResveratrolIBA 07/2009 - 07/2008
3	Epinephrine (Adrenaline)FDA LinkGeneric 09/2004 - 06/2002

Therapy/Procedure

20	Therapeutics 01/2022 - 11/2004
10	Stents 01/2013 - 09/2006
9	Vagus Nerve Stimulation 10/2018 - 01/2004
6	Oral Administration 04/2015 - 11/2009
5	Intravenous Administration 03/2016 - 04/2003
4	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 05/2016 - 01/2005
3	Denervation 08/2017 - 07/2006
3	Intraventricular Infusions 03/2015 - 08/2013
3	Catheter Ablation 01/2012 - 06/2009
3	Extracorporeal Shockwave Therapy 08/2007 - 11/2004
2	Vascular Access Devices (Arterial Line) 01/2022 - 10/2021